http://darklegacycomics.com/ - WoW-based humor
http://www.lfgcomic.com/ - weird "hip" humor mixed into table-top RPG
http://www.schlockmercenary.com/ - 4 Hugo Award nominations, futuristic setting
http://www.girlgeniusonline.com/index.php - multi-award winner, victorian-style steam-punk setting
http://www.pvponline.com/
These have been around for years, and still going.
